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Coastal and Estuarine Studies



  • Fishes—Physiology—Congresses
  • Hatchery fishes—Physiology—Congresses
  • Fish-culture—Congresses
  • Aquaculture—Congresses

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  • 4815 Oceanography: Biological and Chemical: Ecosystems and ecology



Cellular and subcellular toxicity of pollutants: Plasma membrane transport systems as targets

R. K. H. Kinne and E. Kinne-Saffren

Toxicology, similar to its sister science pharmacology, has in recent years moved from observations involving the effect of pollutants on whole animals to the cellular and subcellular level. At these levels its aim is to define the site(s) of action more precisely and to elucidate the mechanism of action of toxins at a molecular level. Once the molecular mechanism is known, it is hoped to develop measures to prevent the influence of pollutants. Ideally, however, - but this is not the topic of this article - similarly measures should be developed from this knowledge to diminish or exclude the formation of pollutants generated by the ever increasing number of people and their demand for decent living conditions. This contribution focusses on the plasma membrane of cells as possible target for pollutants. Such an approach has become possible because techniques have been developed during recent years which allow to study transport systems - and thus the action of pollutants - on individual systems much more precisely [Kinne, 1991 a; Kinne and Kinne-Saffran, 1981; Kinne-Saffran and Kinne, 1990]. Thus definite conclusions on the transport system affected and the sidedness of the action of a toxin, i.e. whether it acts intracellularly or extracellularly, can be drawn.

Citation: Kinne, R. K. H., and E. Kinne-Saffren (1993), Cellular and subcellular toxicity of pollutants: Plasma membrane transport systems as targets, in Aquaculture: Fundamental and Applied Research, Coastal Estuarine Stud., vol. 43, edited by B. Lahlou and P. Vitiello, pp. 287–300, AGU, Washington, D. C., doi:10.1029/CE043p0287.

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