Prognostic cloud schemes in large-scale models are typically formulated in terms of grid-cell average values of cloud condensate concentration q, although variability in q at spatial scales smaller than the grid cell is known to exist. Because the source and sink processes modifying q are nonlinear, the process rates computed using the mean value of q are biased relative to process rates which account for subgrid-scale variability. A preliminary assessment shows that these biases can modify instantaneous process rates by as much as a factor of 2. Observations of q at a continental site suggest that the bias is avoided in current practice through the arbitrary tuning of model parameters. Models might be improved if subgrid-scale variability in q were explicitly considered; several approaches to this goal are suggested.