Previous work has suggested that the strength and latitudinal position of the Southern Hemisphere (SH) mid-latitude westerly winds has an important impact on climate and the Atlantic Meridional Overturning Circulation (AMOC). We probe this hypothesis by conducting ensembles of experiments using the GFDL CM2.1 coupled ocean-atmosphere model with altered SH wind stress. We find, consistent with previous work, that enhanced (reduced) and poleward (equatorward) displaced SH westerly winds lead to an AMOC intensification (weakening). While the AMOC takes more than a century to respond fully to the altered SH winds, initial effects in the North Atlantic can occur within a few decades. The AMOC changes generate SST and surface air temperature responses in the North Atlantic and adjacent continental regions. In the Southern Hemisphere, the atmosphere responds to the altered ocean circulation with a further strengthening and poleward movement of the SH winds, thereby constituting a modest positive feedback.