A new World Ocean atlas of monthly temperature and salinity, based on individual profiles for 2003–2007 (WOA21c), is constructed and compared with the World Ocean Atlas 2001 (WOA01), the World Ocean Atlas 2005 (WOA05), and the data assimilation analysis from the Coupled Data Assimilation (CDA) system developed by the Geophysical Fluid Dynamics Laboratory (GFDL). First, we established a global data management system for quality control (QC) of oceanic observed data both in real time and delayed mode. Delayed mode QC of Argo floats identified about 8.5% (3%) of the total floats (profiles) up to December 2007 as having a significant salinity offset of more than 0.05. Second, all QCed data were gridded at 1° by 1° horizontal resolution and 23 standard depth levels using six spatial scales (large and small longitudinal, latitudinal, and cross-isobath) and a temporal scale. Analyzed mean temperature in WOA21c is warm with respect to WOA01 and WOA05, while salinity difference is less evident. Consistent differences among WOA01, WOA05, and WOA21c are found both in the fully and subsampled data set, which indicates a large impact of recent observations on the existing climatologies. Root mean square temperature and salinity differences and offsets of the GFDL's CDA results significantly decrease in the order of WOA01, WOA05, and WOA21c in most oceans and depths as well. This result suggests that the WOA21c is of use for the collocated assessment approach especially for high-performance assimilation models on the global scale.